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The heart is a pump circulating blood containing nutrients and oxygen to the whole body. In the heart simulator, contraction and relaxation of muscle are reproduced based on the statistical behavior of molecules, which in turn are strongly coupled with the computation of blood flow and pressure. By reproducing a highly realistic human heart whose behavior strictly follows the physical and physiological principles in the computer, the simulator can help doctors choose a treatment option for heart disease patients by accurately predicting its outcome. In fact, projects to determine the optimal operative strategy for individual patients by performing in silico tailor-made cardiac surgeries have already been under way in collaboration with the cardiac surgeons.