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The crew on flight AF1300, which departed from Paris-Charles de Gaulle Airport, alerted authorities on the ground at Adolfo Suárez Madrid-Barajas airport when the passenger complained of feeling unwell and was apparently shivering.
An Air France spokesperson told The Local the passenger has been isolated for medical checks. The passenger was reportedly coming from Africa and was on a connecting flight to Paris.
"Initial indications are that it’s not a case of Ebola," the spokesperson said. "We understand the passenger did not have a temperature."
Medical investigations are ongoing.
Aena and Air France said in separate statements that a passenger on Air France 1300 from Lagos via Paris had started shaking during the flight. Air France said the other passengers disembarked from the plane, which will now be disinfected. The return flight has been canceled.
The spokesperson said the plane has been grounded in Madrid so it can be disinfected as a precautionary measure.
Spain's health ministry confirmed the Ebola emergency protocol had been set in motion but declined to give further details.