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The town in northeastern Arkansas was jarred awake by the explosion that occurred at about 2:30 a.m. local time Sunday morning, according to KAIT.com. The report also said the trains were carrying some hazardous materials, but it wasn't yet known what those materials were.
Weather conditions do not appear to be a factor in the crash. Skies were clear, temperatures were hovering around 80 degrees and winds up to 10 mph were present.
Evacuations began around 3:30 a.m. and authorities kept the area clear for the rest of the morning, the report added. All roads leading into Hoxie, including Highways 67 and 63, were closed after the explosion, according to WREG.com.
A fire involving one of the train engines was reported to still be burning at daybreak, however it is not believed to be threatening any of the toxic cargo.