originally posted by: Soloprotocol
originally posted by: kaylaluv
Could be genetic. Could also be environmental. Did they all live in the same area?
Yeah, within a few miles. I've been scratching my head trying to find a link to this other than the gene pool.
originally posted by: Agartha
a reply to: Soloprotocol
It could be so many reasons, but they have three different types of cancer which makes me think it's not a genetic mutation that is passed on genetically (but I am not an oncologist expert).
I would suggest to go see your doctor and give him all the details: types of cancer, ages, lifestyle, etc. and see what he/she says about your sons. If a family link is not possible, then try to find out where they lived, if they have all ever lived together, where, drinking water sources, asbestos in the house...so many different factors too look at.
But don't panic, it would be worrisome if they've all had the same type of cancer.
Your sons will be ok, just stay positive and strong.......sending blessings to you and your family.
originally posted by: Soloprotocol
a reply to: the owlbear
Not Rural per say...small village. all keen golfers though so they would be at the golf course 3/4 day a week.
Acute leukaemia is known to develop in many cases of benzene-induced pancytopenia . This is a report of the development of acute leukaemia in a patient who had apparently recovered from pancytopenia after chronic exposure to a weed killer, 2-methyl-4-chlorphenoxyacetic acid.
A study published in the Journal of the National Cancer
Institute ﬁnds that household and garden pesticide use
can increase the risk of childhood leukemia as much as
■ Studies show that children living in households where
pesticides are used suffer elevated rates of leukemia, brain
cancer and soft tissue sarcoma.9
■ Pesticides can increase susceptibility to certain cancer
originally posted by: rickymouse
a reply to: Soloprotocol
I got some of that radium 226 in a vial in a watch painting kit. I found it with my geiger counter. I moved it to the garage in a metal cabinet. Half the basement was above the normal radiation levels of the house.
Surprising how many people are afraid of that stuff, an occasional exposure does not really hurt you but a constant long term exposure could cause problems. People fear things that shouldn't be feared. I don't think that making lipstick out of it would be advisable though.
I slept with my head next to a Big Ben clock when I was young. I was considered normal back then, believing what society taught me. Maybe I should put one of my Little Ben clocks on the nightstand so I can return back to blissful ignorance. I can't really comprehend these two things being related
Controlling fear by modifying DNA
....Dr Bredy said they had discovered a novel mechanism of gene regulation associated with fear extinction, an inhibitory learning process thought to be critical for controlling fear when the response was no longer required.
“Rather than being static, the way genes function is incredibly dynamic and can be altered by our daily life experiences, with emotionally relevant events having a pronounced impact,” Dr Bredy said.
He said that by understanding the fundamental relationship between the way in which DNA functions without a change in the underlying sequence, future targets for therapeutic intervention in fear-related anxiety disorders could be developed.
“This may be achieved through the selective enhancement of memory for fear extinction by targeting genes that are subject to this novel mode of epigenetic regulation,” he said.
Mr Xiang Li, a PhD candidate and the study’s lead author, said fear extinction was a clear example of rapid behavioural adaptation, and that impairments in this process were critically involved in the development of fear-related anxiety disorders.
“What is most exciting is that we have revealed an epigenetic state that appears to be quite specific for fear extinction,” Mr Li said.
Dr Bredy said this was the first comprehensive analysis of how fear extinction was influenced by modifying DNA.
“It highlights the adaptive significance of experience-dependent changes in the chromatin landscape in the adult brain,” he said.
...The genetic traits these people share makes them susceptible to cancer if they don't eat a diet that their body recognizes or matches their genetics.
...genetic and environmental are strongly related
originally posted by: Glassbender777
My nephew 9 is going through leaukiemia treatment, and there are TONs of reason why they think he got it for the second time. paint, light bulbs, chemicals, ....
Epigenetic therapy of cancer: past, present and future
The initiation and progression of cancer is controlled by both genetic and epigenetic events. Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations are potentially reversible, allowing the malignant cell population to revert to a more normal state. With the advent of numerous drugs that target specific enzymes involved in the epigenetic regulation of gene expression, the utilization of epigenetic targets is emerging as an effective and valuable approach to chemotherapy as well as chemoprevention of cancer.
‘Epigenetic’ is a term used to describe mitotically and meiotically heritable states of gene expression that are not due to changes in DNA sequence1. Epigenetic events are important in all aspects of biology, and research dur- ing the past decade has shown that they have a key role in carcinogenesis and tumour progression. Two of the most studied epigenetic phenomena are DNA methylation and histone tail modifications (BOX 1).
Epigenetic therapy clinically active against several blood cancers
Patients with a variety of hematologic cancers benefited from treatment with OTX015, a member of a new class of investigational epigenetic therapies that block the activity of bromodomain and extraterminal (BET)-bromodomain proteins. These phase I clinical trial results were presented at the American Association for Cancer Research 2014 Annual Meeting, in San Diego, California.
BET-bromodomain proteins have an important role in controlling whether a gene is turned on or off. They work by attaching to special epigenetic flags on the genome. The positioning of many epigenetic flags is abnormal in many different types of cancer, and this can inappropriately turn genes on or off, helping drive these cancers.
“OTX015 is a potent, small-molecule inhibitor of the BET-bromodomain proteins BRD2, 3, and 4,” said Esteban Cvitkovic, MD, founder and CEO of OncoEthix, the sponsor of this trial. “Preclinical data showed that it may be effective against a wide range of hematologic malignancies. This ongoing study is designed to determine the recommended dose and schedule of OTX015 to be given orally as a single agent to patients with hematologic malignancies.
“We have been excited to see that several leukemia and lymphoma patients, having failed all available standard therapies, have durable, objective responses to monotherapy with oral OTX015 at doses that have little or no toxicity,” added Cvitkovic. “As far as we know, this is the first clinical evidence that BET-bromodomain inhibitors, a new family of anticancer agents, may have a role in the treatment of human malignancies.”