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just give me more life now.... let's worry about the side effect after I gained my extra 30 or 40 years.... by then they will have cured the side effects anyway!
Minireview: NAD+, a circadian metabolite with an epigenetic twist.
A wide variety of endocrine, physiological, and metabolic functions follow daily oscillations. Most of these regulations are controlled at the level of gene expression by the circadian clock and, a remarkably coordinated transcription-translation machinery that exerts its function in virtually all mammalian cells. A large fraction of the genome is under control of the circadian clock, a regulation that is achieved through dynamic changes in chromatin states. Recent findings have demonstrated intimate connections between the circadian clock and epigenetic control. The case of nicotinamide adenine dinucleotide, which modulates the circadian activity of the deacetylase sirtuin 1, constitutes a paradigmatic example of the link between cyclic cellular metabolism and chromatin remodeling. Indeed, the clock transcriptional feedback loop is interlocked with the enzymatic loop of the nicotinamide adenine dinucleotide salvage pathway.
.....Stallone on the other hand looks like he's had lots of surgery, just like his mum....his face looks stiff and 'plastichy'.
Complications his mother suffered during labor forced her obstetricians to use two pairs of forceps during his birth; misuse of these accidentally severed a nerve and caused paralysis in parts of Stallone's face. As a result, the lower left side of his face is paralyzed – including parts of his lip, tongue, and chin – an accident which has given Stallone his snarling look and slightly slurred speech.
“Nicotinamide, also known as niacinamide and nicotinic acid amide, is the amide of nicotinic acid (vitamin B3/ niacin). ....n cells, niacin is incorporated into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), although the pathways for nicotinamide and nicotinic acid are very similar. NAD+ and NADP+ are coenzymes in a wide variety of enzymatic oxidation-reduction reactions. (ref)”
Observation 1: The body absolutely needs to have an adequate supply of niacin or niacinamide available to make the amounts of NAD and NADP required for health. Further, this must come from dietary sources, foods or supplements.
Observation 2: The research literature related to therapeutic use of niacin/niacinamide is at first confusing expressing different viewpoints that have emerged during different periods of time and representing different ways of looking at the effects of substance. Some articles cite reasons why large doses of niacin may promote longevity, and other articles cite reasons why such use may shorten life.
Observation 3: For about 40 years large doses of niacin have been used for several therapeutic purposes. Many physicians currently prescribe large doses of niacin for lipid control and other purposes. Mild benefits seem to exist in some areas like raising HDL cholesterol. The long-term consequences of repeatedly taking large doses are unknown.
Observation 4: Large scale niacin dosage profoundly affects multiple genes through multiple pathways producing both wanted and unwanted results. While many researchers are excited by the possibilities of niacin-related therapies for a variety of conditions, the one thing they agree on is a need for further understanding of the pathways involved.
Observation 5: The sirtuin-related pathways involving the niacin metabolites NAD and NADP are among those related to niacin most intensely studied in recent years. Large doses of niacin/niacinamide inhibit the expression of SIRT1 and therefore prevent the health and longevity benefits associated with expression of SIRT1.
I knew of a chemical before this that did almost the same thing. You can buy it from research chemical suppliers. Not sure this is anything but that original chemical.
A New—and Reversible—Cause of Aging
By DAVID CAMERON
December 19, 2013
Nicotinamide Mononucleotide reverses aging in mice in one week
"Researchers have discovered a cause of aging in mammals that may be reversible.
The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria. As communication breaks down, aging accelerates. By administering a molecule naturally produced by the human body, scientists restored the communication network in older mice. Subsequent tissue samples showed key biological hallmarks that were comparable to those of much younger animals."
Nicotinamide Adenine Dinucleotide Phosphate
NAD+ and NADH in cellular functions and cell death.
"Increasing evidence has indicated that NAD+ and NADH play critical roles not only in energy metabolism, but also in cell death and various cellular functions including regulation of calcium homeostasis and gene expression. It has also been indicated that NAD+ and NADH are mediators of multiple major biological processes including aging. NAD+ and NADH produce the biological effects by regulating numerous NAD+/NADH-dependent enzymes, including dehydrogenases, poly(ADP-ribose) polymerases, Sir2 family proteins (sirtuins), mono(ADP-ribosyl)transferases, and ADP-ribosyl cyclases. Of particular interest, NAD+-dependent generation of ADP-ribose, cyclic ADP-ribose and O-acetyl-ADP-ribose can mediate calcium homeostasis by affecting TRPM2 receptors and ryanodine receptors; and sirtuins and PARPs appear to play key roles in aging, cell death and a variety of cellular functions. It has also been indicated that NADH and NAD+ can be transported across plasma membranes of cells, and that extracellular NAD+ may be a new signaling molecule. Our latest studies have shown that intranasal NAD+ administration can profoundly decrease ischemic brain damage."