posted on Mar, 22 2014 @ 12:23 PM
This a study done on a 33 year old woman with both HIV and Lupus. Since her immune sytem is hyper active, due to the autoimmune disease Lupus, and is
fighting off HIV, not curing it. Her body produces these broadly neutralizing antibodies that are more effective in fighting HIV than other
The study helped scientists to better understand how the immune system makes broadly neutralizing antibodies, that could be used to peoduce vaccines
in the future.
Very interesting read.
One woman's uncommon ability to fight her HIV infection may provide new insights for developing a vaccine that triggers a special immune response
against the viral disease, researchers said.
Scientists studied a 33-year old woman who had a rare combination of lupus, an autoimmune disease in which an overactive immune system attacks the
body's cells and tissues, along with HIV, which damages and weakens the immune system.
The researchers found that in response to her HIV, the woman's immune system produced what are called "broadly neutralizing antibodies," which are
effective in controlling HIV.
Very few people infected with HIV create these antibodies, because the immune system typically keeps their production in check. However, it has been
suggested that impaired immune systems, such as those of people with lupus, would allow for the production of these antibodies, the researchers
"We found that the patient did indeed make these important antibodies, and by determining how this immune response occurred, we have enhanced our
understanding of the process involved," said study researcher Dr. Barton Haynes, director of the Duke University Human Vaccine Institute.
Does lupus hold the key?
A few years ago, Haynes and his colleagues found that some broadly neutralizing antibodies to HIV also attack the body's own tissues, suggesting the
reason they are not routinely made is that the immune system sees them as harmful.
These antibodies looked a lot like those the research team had been studying in lupus patients who were not infected with HIV. "It was a clue that the
antibody is coming from the same pool of immune cells that give rise to auto-reactive antibodies in autoimmune disease," Haynes said.
edit on 22-3-2014 by Jennyfrenzy because: (no reason given)