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The Blue Fugates are an extended family from the Appalachian Mountains famous for having a high occurrence of the rare disorder methemoglobinemia. Martin Fugate, a French immigrant and patriarch of the family, settled near Hazard, Kentucky circa 1800. He and his wife were carriers of the recessive methemoglobinemia (met-H) gene, which limited and/or stopped the body's production of the enzyme diaphorase (which breaks down methemoglobin into hemoglobin in red blood cells). The absence of this enzyme produced a disproportionate amount of methemoglobin in the blood, tinting it blue. Because each was only a carrier, neither Martin nor his wife suffered from the condition. However, by Mendelian inheritance, 25% of their children would be homozygous recessive and suffer from the condition, while 50% of their children would be asymptomatic heterozygous carriers like their parents.
Despite their bluish tint, the Fugates did not have any of the numerous sequelae associated with severe methemoglobinemia. As of 1982 only two or three members of the family had the condition (Carnegie 1997, p. 214)
Originally posted by debris765njuThe glow is caused by an outside stimulus that is faintly visible in the air around me. "There is more in heaven and earth than is drempt of in your philosophy, Horatio".
The people I have heard about are:
The deljar nar